NONINFECTIOUS INFLAMMATION AND SYSTEMIC DISEASESOF THE VULVA

Abstract

Noninfectious, inflammatory, and systemic diseases of the vulva represent a diagnostically challenging and clinically significant group of disorders. These conditions include inflammatory dermatoses such as eczema, psoriasis, lichen planus, lichen sclerosus, autoimmune blistering diseases, drug reactions, and systemic inflammatory disorders, including Crohn’s disease and Behçet’s syndrome. Vulvar dermatoses often present with overlapping clinical features such as erythema, pruritus, erosions, ulceration, and scarring, making accurate diagnosis essential for appropriate management. Many of these disorders significantly impair quality of life due to pain, dyspareunia, psychological distress, and fear of malignancy. This review provides a comprehensive overview of the clinical presentation, differential diagnosis, histopathological features, and evidence-based management strategies for noninfectious vulvar inflammatory disorders, along with a systematic review of Ulcus vulvae acutum (Lipschutz ulcer) and a proposed diagnostic algorithm