Conducting empirical research in Nigeria presents unique challenges that can hinder the progress and quality of research outcomes. This abstract provides an overview of the key challenges faced by researchers in Nigeria, highlighting their implications and potential solutions. Limited research funding is a significant obstacle, as it restricts the ability to conduct comprehensive studies and access necessary resources. Inadequate research infrastructure, including poorly equipped laboratories and libraries, hampers data collection, analysis, and storage processes. Data collection difficulties arise from a large and diverse population, poor record-keeping systems, and limited data accessibility. Additionally, cultural factors, language barriers, and social sensitivities can affect respondents’ willingness to participate or provide honest responses, leading to biased or incomplete data. Addressing these challenges requires increased research funding, enhanced research infrastructure, capacity building, improved ethical guidelines, and collaboration among stakeholders. Governments, private organizations, and international collaborations should allocate more resources to research funding and infrastructure development. By overcoming these challenges, researchers in Nigeria can unlock the potential for valuable contributions to knowledge and foster sustainable development in the country.