The study examined teacher-students interactive teaching strategies and students’ academic outcomes of secondary school students in Ikot Ekpene Local Government. In order to carry out this study, specified research objectives. The research design for this study is a survey design. The population of the study consisted of all the 8792 Junior Secondary students from the 11 secondary schools in Ikot Ekpene Local Government Area. Simple random sampling technique was used to select 313 respondents out of the population. The instrument used for data collection was questionnaire. The instrument was validated by experts in Test and Measurement. Crombach Alpha reliability technique was used for testing the reliability of the instrument and reliability index of .72 was realized, hence the instrument was regard as being reliable. Data from completed questionnaires was subjected to descriptive and PPMC analysis. The finding showed and concludes that teacher-Students Interactive Teaching Strategies promotes students’ academic outcomes of secondary school students in Ikot Ekpene Local Government. Based on the findings in this study and the discussions that followed, it is recommended that Government at all tiers through State Secondary Education Board should embark on training and retraining programmes for teachers to enhances their students-students teaching interactive teaching strategies and this we know, will foster students’ academic outcomes in English Language.